‘Gene misbehaviour’, where genes are active when they were expected to be switched off, is surprisingly common in the healthy human population, scientists have found. Several mechanisms behind these gene activity errors have also been identified, which may help to guide new precision medicine approaches, or enable the development of targeted therapies to correct gene expression. The human genome contain about 19,900 genes, which form a key part of the instruction manual for our bodies by encoding the proteins that carry out cell functions. Gene regulation turns these gene instructions on and o…