In a study conducted by Weill Cornell Medicine scientists, a novel human neuron model has been developed that simulates the spread of tau protein aggregates in the brain. This phenomenon is a key driver behind cognitive decline observed in Alzheimer’s disease and frontotemporal dementia. The study, published in Cell00306-4), helps to identify potential targets for drug development that could block the spread of tau aggregates. Tau aggregates are clumps of misfolded tau proteins that accumulate inside the neurons of the brain, disrupting their normal function and leading to cell death. These ag…
