By Tzvi Machlin The Pittsburgh Steelers have lost three of their last four games and their playoff hopes are by no means guaranteed. But they could be without two key players for Saturday’s game against the Indianapolis Colts. According to ProFootballTalk, two Steelers players are being listed as questionable for the game. One is pass rusher Alex Highsmith and the other is left guard Isaac Seumalo. Highsmith was limited in practice on Tuesday and Wednesday but might be a full participant on Thursday. In 13 games he has 6.0 sacks, 49 tackles, an interception, two forced fumbles and 16 QB hits. …