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Renaissance Technologies, the hedge fund founded by legendary mathematician and former National Security Agency code breaker Jim Simons, recently disclosed its latest stock holdings in a 13F filing with the U.S. Securities and Exchange Commission on Aug. 9. What Happened: The filing reveals significant changes in the fund’s portfolio, reflecting the quantitative strategies that have made Renaissance one of the most successful hedge funds in history. Leading the pack isNovo Nordisk A/S (NYSE:NVO), a Danish pharmaceutical giant, which accounts for 2.22% of Renaissance’s portfolio with a market v…