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A diagnosis of treatment-resistant depression (TRD) sounds like the end of the road. Fortunately, it’s not. “Depression, even if it proves to be stubborn, is a very treatable condition,” says psychiatrist and psychotherapist Dr Mazda Adli, head of the affective disorders research division at Charité university hospital in Berlin. So if your doctor says your depression is “treatment-resistant,” it doesn’t mean nothing more can be done for you. The term is used when adequate dosages of at least two different antidepressants, administered for four to six weeks, don’t improve your symptoms. “It’s …

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