A new study published in Science Advances has shed light on the complex mechanisms behind the sex differences observed in autism. The research suggests that increased dosage of a gene known as Ube3a can influence autism-related traits in a manner that differs between males and females. By examining mice with extra copies of this gene, researchers found significant sex-specific effects on brain connectivity and behavior, offering insights into why autism is more prevalent in males. Autism, or autism spectrum disorder (ASD), is a complex neurodevelopmental condition characterized by challenges i…